Cardioprotective Effect of Thiazide-Like Diuretics: A Meta-Analysis
نویسندگان
چکیده
منابع مشابه
Comparison of thiazide‐like diuretics versus thiazide‐type diuretics: a meta‐analysis
Thiazide diuretics are widely used for the management of hypertension. In recent years, it has been actively debated that there is interchangeability of thiazide-type diuretics hydrochlorothiazide and thiazide-like diuretics including indapamide and chlorthalidone for the treatment of hypertension. With the purpose of seeking out the best thiazide diuretic for clinicians, we summarized the exis...
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Published observational estimates of the effect of thiazide diuretics on osteoporotic fracture risk vary from a 70% reduction to a 60% increase but there have been no randomized controlled trials. The aims of this study were to use the technique of meta-analysis to attempt to resolve this conflict and to explore whether duration and/or dose of therapy has an effect on osteoporotic fracture risk...
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Thiazide diuretics are recommended as first-line therapy for hypertension and are among the most commonly prescribed drugs worldwide. According to their molecular structure, thiazide diuretics can be divided in thiazide-type (TT) and thiazide-like (TL) diuretics. TL diuretics have a longer elimination half-life compared with TT diuretics and have been shown to exert additional pharmacological e...
متن کاملDiuretics in the treatment of hypertension. Part 1: thiazide and thiazide-like diuretics.
INTRODUCTION Thiazides and thiazide-like diuretics inhibit the electroneutral Na(+)-Cl(-) cotransporter located on the apical membrane of the early segment of the distal convoluted tubule. They have been widely prescribed over 60 years in the treatment of hypertension and various edematous states. AREAS COVERED Thiazide diuretics reduce blood pressure (BP), although the mechanisms by which th...
متن کاملMechanism of antihypertensive effect of thiazide diuretics.
Hemodynamic studies were carried out before and during 8 weeks of treatment with hydrochlorothiazide 50 mg. twice daily in 11 hypertensive patients. Forty-eight hours after beginning treatment there was a significant reduction in blood pressure, cardiac output, plasma volume, and extracellular fluid volume (thiocyanate space) while total peripheral resistance increased. After 6 and 8 weeks of t...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 2015
ISSN: 0895-7061,1941-7225
DOI: 10.1093/ajh/hpv050